Publication

2025

Articles

• "Thermolides D and E: Total synthesis and stereochemical revision"
  Peng, W.; Han, F.; Liu, J.; Wang, C.; Minami, A.; Oikawa, H.; Guo, Y.; Ye, T.*
  Org. Lett. 27, 8183-8188 (2025).

  • DOI: 10.1021/acs.orglett.5c01326

  International Collaboration: Prof. Ye (Peking University Shenzhen Graduate School)
• "Isolation and identification of xanthone, benzofuran, and spirolactone derivatives from Dinemasporium parastrigosum KT4144 and their plausible biosynthetic pathways"
  Kirisawa, K.; Sato, S.; Minami, A.; Tanaka, K.; Hashimoto, M.*
  J. Nat. Prod. 88, 1453-1462 (2025).

  • DOI: 10.1021/acs.jnatprod.5c00376

  Interdisciplinary Research: Prof. Hashimoto (Hirosaki University)
• "Chain-length preference of trans-acting enoylreductases involved in the biosynthesis of fungal polyhydroxy polyketides"
  Takekawa, Y.; Takino, J.; Sato, S.; Oikawa, H.*; Ose, T.*; Minami, A.*
  Biochem. Biophys. Res. Commun. 761, 151737 (2025).

  • DOI: 10.1016/j.bbrc.2025.151737

  Interdisciplinary Research: Prof. Ose (Hokkaido University)／open access
• "A fungal transcription factor converts a beneficial root endophyte into an anthracnose leaf pathogen"
  Ujimatsu, R.; Takino, J.; Aoki, S.; Nakamura, M.; Haba, H.; Minami, A.; Hiruma, K.*
  Curr. Biol. 35, 1989-2005 (2025).

  • DOI: 10.1016/j.cub.2025.03.026

  Interdisciplinary Research: Prof. Hiruma (The University of Tokyo)／open access
• "Biochemistry and chemoinformatics guided classification of hirsutane sesquiterpenes isolated from mushroom"
  Liu, Y.; Nishishita, J.; Liu, C.; Oikawa, H.*; Minami, A.*
  JACS Au 5, 740-746 (2025).

  • DOI: 10.1021/jacsau.4c00983

  International Collaboration: Prof. Liu (Northeast Forestry University)／open access

Preprints

• "Predicting protein complexes in biosynthetic gene clusters"
  Moriwaki, Y.*; Shiraishi, T.; Katsuyama, Y.; Matsuda, K.; Ose, T.; Minami, A.; Oikawa, H.; Kuzuyama, T.; Ishitani, R.; Terada, T.
  BioRxiv (2025).

  • DOI: 10.1101/2025.10.26.684697

  Interdisciplinary Research: Prof. Moriwaki (Institute of Science Tokyo)

2024

Articles

• "Bioinformatics-guided reconstitution of biosynthetic machineries of fungal eremophilane sesquiterpenes"
  Sato, Y.; Shi, X.; Ye, Y.; Domon, S.; Takino, J.; Ozaki, T.; Liu, C.; Oikawa, H.*; Minami, A.*
  ACS Chem. Biol. 19, 861-865 (2024).

  • DOI: 10.1021/acschembio.4c00040

  International Collaboration: Prof. Ye (HUST) and Prof. Liu (Northeast Forestry University)
• "Subcellular compartmentalized localization of transmembrane proteins essential for production of fungal cyclic peptide cyclochlorotine"
  Katayama, T.; Jiang, Y.; Ozaki, T.*; Oikawa, H.*; Minami, A.*; Maruyama, J.*
  Biosci. Biotechnol. Biochem. 88, 1279-1288 (2024).

  • DOI: 10.1093/bbb/zbae122

  Interdisciplinary Research: Prof. Maruyama (The University of Tokyo) and Prof. Ozaki (Tohoku University)／open access
• "Versatile filamentous fungal host highly-producing heterologous natural products developed by genome editing-mediated engineering of multiple metabolic pathways"
  Saito, N.; Katayama, T.; Minami, A.; Oikawa, H.; Maruyama, J.*
  Commun. Biol. 7, 1263 (2024).

  • DOI: 10.1038/s42003-024-06958-0

  Interdisciplinary Research: Prof. Maruyama (The University of Tokyo)／open access

Preprints

• "A fungal transcription factor BOT6 facilitates the transition of a beneficial root fungus into an adapted anthracnose pathogen."
  Ujimatsu, R.; Takino, J.; Nakamura, M.; Haba, H.; Minami, A.; Hiruma, K.*
  BioRxiv (2024).

  • DOI: 10.1101/2024.03.10.584252

  Interdisciplinary Research: Prof. Hiruma (The University of Tokyo)

2023

Articles

• "Oxidative bicyclic ring system formation involving indole diterpene biosynthesis: Remarkable substrate tolerance of a prenyltransferase and flavoprotein oxidase"
  Liu, Y.; Ozaki, T.; Minami, A.*; Oikawa, H.*
  Tetrahedron Lett. 117, 154374 (2023).

  • DOI: 10.1016/j.tetlet.2023.154374
• "A fungal sesquiterpene biosynthesis gene cluster critical for mutualist-pathogen transition in Colletotrichum tofieldiae"
  Hiruma, K.*; Aoki, S.; Takino, J.; Higa, T.; Utami, Y. D.; Shiina, A.; Okamoto, M.; Nakamura, M.; Kawamura, N.; Ohmori, Y.; Sugita, R.; Tanoi, K.; Sato, T.; Oikawa, H.; Minami, A.; Iwasaki, W.; Saijo, Y.
  Nat. Commun. 14, 5228 (2023).

  • DOI: 10.1038/s41467-023-40867-w

  Interdisciplinary Research: Prof. Hiruma (The University of Tokyo)／open access
• "Total biosynthesis of melleolides from Basidiomycota fungi: Mechanistic analysis of the multi-functional GMC oxidase Mld7"
  Fukaya, M.#; Nagamine, S.#; Ozeki, M.; Matsuyama, T.; Sato, M.; Miyamoto, K.; Kawagishi H.; Watanabe, K.; Ozaki, T.; Uchiyama, M.; Oikawa, H.*; Minami, A.*
  Angew. Chem. Int. Ed. 62, e202308881 (2023).

  • DOI: 10.1002/anie.202308881

  Interdisciplinary Research: Prof. Kawagishi (Shizuoka University) and Prof. Uchiyama (The University of Tokyo)

Reviews

• "Recent advances in the biosynthesis of ribosomally synthesized and posttranslationally modified peptides of fungal origin"
  Ozaki, T.; Minami, A.; Oikawa, H.*
  J. Antibiot. 76, 3-13 (2023).

  • DOI: 10.1038/s41429-022-00576-w
• "Controlled chemical construction in nature: Unified biogenesis accounting for synthesis of fungal dimeric anhydrides"
  Minami, A.*
  Bull. Chem. Soc. Jpn. 96, 1216-1223 (2023).

  • DOI: 10.1246/bcsj.20230187
• "Biosynthesis of indole diterpenes: Reconstitution approach in heterologous host"
  Ozaki, T.; Minami, A.*; Oikawa, H.*
  Nat. Prod. Rep. 40, 202-213 (2023).

  • DOI: 10.1039/D2NP00031H

Books

• "A new trend in biosynthetic studies of natural products: The bridge between the amino acid sequence data and the chemical structure"
  Minami, A.
  New Tide of Natural Product Chemistry (2023).

2022

Articles

• "Heterologous expression of a polyketide synthase ACRTS2 in Aspregillus oryzae produces host selective ACR-toxins: Co-production of minor metabolites"
  Kotani, A.; Ozaki, T.*; Takino, J.; Mochizuki, S.; Akimitsu, K.; Minami, A.*; Oikawa, H.*
  Biosci. Biotechnol. Biochem. 86, 287-293 (2022).

  • DOI: 10.1093/bbb/zbab214

  Interdisciplinary Research: Prof. Akimitsu (Kagawa University)
• "Mechanism of S-adenosyl-L-methionine C-methylation by cobalamin-dependent radical S-adenosyl-L-methionine methylase in 1-amino-2-methylcyclopropanecarboxylic acid biosynthesis"
  *Kudo, F; Minato, A; Sato, S; Nagano, N; Maruyama, C; Hamano, Y. Hashimoto, J; Kozone, I; Shin-ya, K; *Eguchi, T
  Org. Lett. 24, 49, 8975-8979 (2022).

  • DOI: 10.1021/acs.orglett.2c03555
• "Biosynthetic machineries of anthraquionones and bisanthraquinones in Talaromyces islandicus"
  Fukaya, M.; Ozaki, T.; Minami, A.*; Oikawa, H.*
  Biosci. Biotechnol. Biochem. 86, 435-443 (2022).

  • DOI: 10.1093/bbb/zbac009
• "Structure and biosynthesis of ribosomal lipopeptide antibiotic albopeptins"
  Oikawa, H.*; Mizunoue, Y.; Nakamura, T.; Fukushi, E.; Jiang, Y.; Ozaki, T.; Minami, A.; Isono, K.
  Biosci. Biotechnol. Biochem. 86, 717-723 (2022).

  • DOI: 10.1093/bbb/zbac039

  JSBBA Journal Paper Award
• "Elucidation of late-stage biosynthesis of phomoidride: Proposal of cyclization mechanism affording characteristic 9-membered ring of fungal dimeric anhydride"
  Yamamoto, S.; Matsuyama, T.; Ozaki, T.*; Takino, J.; Sato, H.; Uchiyama, M.*; Minami, A.*; Oikawa, H.*
  J. Am. Chem. Soc. 144, 20998-21004 (2022).

  • DOI: 10.1021/jacs.2c09308

  Interdisciplinary Research: Prof. Uchiyama (The University of Tokyo) and Prof. Ozaki (Tohoku University)

Reviews

• "Characterization of the cobalamin-dependent radical S-adenosyl-L-methionine enzyme C-methyltransferase Fom3 in fosfomycin biosynthesis"
  Sato, S; Kudo, F; *Eguchi, T
  Methods Enzymol. 669, 45_70 (2022).

  • DOI: 10.1016/bs.mie.2021.11.025

Books

• "麹菌が切り拓く天然物化学～麹菌を利用した生物活性天然物の生産"
  南 篤志、尾_太郎、及川英秋
  発酵・醸造食品の最前線II（食品） (2022).

2021

Articles

• "Biochemical and mutational analysis of radical S-adenosyl-L-methionine adenosylhopane synthase HpnH from Zymomonas mobilis reveals that the conserved residue cysteine-106 reduces a radical intermediate and determines the stereochemistry"
  Sato, S; *Kudo, F; Rohmer, M; *Eguchi, T
  Biochemistry 60, 38, 2865-2874 (2021).

  • DOI: 10.1021/acs.biochem.1c00536
• "Biosynthesis of cyclochlorotine: Identification of the genes involved in oxidative transformations and intramolecular O,N-transacylation"
  Jiang, Y.; Ozaki, T.*; Liu, C.; Igarashi, Y.; Ye, Y.; Tang, S.; Ye, T.; Maruyama, J.; Minami, A.*; Oikawa, H.*
  Org. Lett. 23, 2616-2620 (2021).

  • DOI: 10.1021/acs.orglett.1c00525

  Interdisciplinary Research: Prof. Maruyama (The University of Tokyo)
• "Genome-based discovery of enantiomeric pentacyclic sesterterpenes catalyzed by the fungal bifunctional terpene synthase"
  Jiang, L.; Zhang, X.; Sato, Y.; Zhu, G.; Minami, A.; Zhang, W.; Ozaki, T.; Zhu, B.; Wang, Z.; Wang, X.; Lv, K.; Zhang, J.; Wang, Y. -H.; Gao, S. -S.; Liu, C.; Hsiang, T.; Zhang, L.; Oikawa, H.*; Liu, X.*
  Org. Lett 23, 4645-4650 (2021).

  • DOI: 10.1021/acs.orglett.1c01361

  International Collaboration: Prof. Liu (East China University of Science and Technology)
• "Biochemistry-guided prediction of absolute configuration of fungal reduced polyketide"
  Takino, J.; Kotani, A.; Ozaki, T.; Peng, W.; Yu, J.; Guo, Y.; Mochizuki, S.; Akimitsu, K.; Hashimoto, M.; Ye, T.*; Minami, A.*; Oikawa, H.*
  Angew. Chem. Int. Ed. 60, 23403-23411 (2021).

  • DOI: 10.1002/anie.202110658

  Collaborative Research with Prof. Ye (Peking University Shenzhen Graduate School)
• "Biosynthetic studies of phomopsins unveil posttranslational installation of dehydroamino acids by UstYa family proteins"
  Sogahata, K.; Ozaki, T.*; Igarashi, Y.; Naganuma, Y.; Liu, C.; Minami, A.*; Oikawa, H.*
  Angew. Chem. Int. Ed. 60, 25729-25734 (2021).

  • DOI: 10.1002/anie.202111076